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The Golgi apparatus is correctly identified as the component responsible for packaging substances synthesized in the endoplasmic reticulum (ER). Once proteins and lipids are produced in the ER, they are transported to the Golgi apparatus, where they undergo further modifications, sorting, and packaging into vesicles for transport to their final destinations within or outside the cell. The Golgi apparatus plays a critical role in processing these macromolecules, ensuring that they are properly modified and delivered to the correct locations, which is essential for the proper functioning of the cell.

Ribosomes are involved in protein synthesis, translating mRNA into polypeptide chains, but they do not package substances. The nucleus houses the cell's genetic material and is the site of transcription, not the packaging of synthesized products. Vesicles serve as transport vehicles for the substances but are not responsible for the initial packaging; they are instead formed by the Golgi apparatus after it modifies substances. Thus, the Golgi apparatus serves a unique and essential function in the cell, directly linked to the packaging of substances synthesized in the ER.